GENETIKA, Vol. 21, No.3 (1989)
D. MARINKOVIĆ
POPULATION-GENETIC APPROACHES TO THE STUDY OF YUGOSLAVIAN INHIBITANTS [Abstract]
R. HADŽISELIMOVIĆ, R. TERZIĆ and LJ. BERBEROVIĆ
GENETIC VARIABILITY AND REPRODUCTIVE ISOLATION OF LOCAL HUMAN POPULATIONS IN BOSNIA AND HERCEGOVINA [Abstract]
Marija DEBEVEC
THE APPLICATION OF CYTOGENETIC ANALYSIS TO SAMPLES OF CHORIONIC VILLI [Abstract]
Z. SINGER, K. PROFETA, M. PODOBNIK, M. BULIĆ, S. CIGLAR, V. KUKURA and N. SMILJANIĆ
CAUSES AND INCIDENCE OF HABITUAL ABORTIONS IN OUR POPULATION [Abstract]
M. VELISAVLJEV and R. TERZIĆ
HEREDITARY AND CONGINITAL MALFORMATIONS IN NEWBORN INFANTS IN VOJVODINA AND BOSANSKA KRAJINA REGIONS [Abstract]
B. RAJHVAN and A. KURJAK
FETAL TISSUE BIOPSY [Abstract]
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 179-188
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 575.1
Original scientific paper
POPULATION-GENETIC APPROACHES TO THE STUDY OF YUGOSLAVIAN INHIBITANTS
D. MARINKOVIĆ
Faculty of Biology, Fac. Sci., University of Belgrade 11000 Belgrade, Yugoslavia
Abstract
Marinković D. (1989): Population-genetic approaches to the study of Yugoslavian inhabitants, - Genetika, Vol. 21, No. 3, 179-188.
The approaches which we may use in studying human populations, could be: demographic, anthropological, phenotypic (Le. morphophysiological), medicogenetical (Le. epidemic logical), biochemical, cytogenetical, ontogenetica! and evolutionary.
Population-genetic analyses of Yugoslavian inhabitants are still not so numerous, being directed to: (1) The discovery of specific types of trait variation in studied human populations, and (2) The explanation of the "nature-nurture" relationships, for the diseases which have an increased frequency in such populations.
As characteristic instances for the significance of genetic factors in determining some complex diseases, Balkan (Endemic) nephropathy, acute appendicitis, diabetes mellitus, and some other illnesses, have been considered. The possibility of the influence of increased genetic loads in the studied populations, has been taken into consideration also.
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 189-202
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 575.1
Original scientific paper
GENETIC VARIABILITY AND REPRODUCTIVE ISOLATION OF LOCAL HUMAN POPULATIONS IN BOSNIA AND HERCEGOVINA
R. HADŽISELIMOVIĆ, R. TERZIĆ and LJ. BERBEROVIĆ
Faculty of Science, University of Sarajevo, 71000 Sarajevo and
Faculty of Medicine, University of Banja Luka, 78000 Banja Luka Yugoslavia
Abstract
Hadžiselimović R., R, Terzić and Lj. Berberović (1989): Genetic variability and reproductive isolation of local human populations in Bosnia and Herzegovina. - Genetika, Vol. 21, No. 3, 189-202.
The genetic distance regarding the complex of 15 "adaptive natural" phenotypic systems was studied in a group of 15 local populations. The results of this analysis showed a relatively low level of genetic heterogeneity. No significant correlation was found between genetic distance and observed measures of reproductive isolation (marital and spatial distance, coefficient of endogamy), or other factors (population size, reproductive level).
Parallel investigations of the possible connection were carried out by analysing the relations between marital distance and frequency of the 29 congenital anomalies in the sample of now born infants. Certain indications of a (negative) correlation between marital distance and the total frequency of the studied anomalies were' observed only in the (sub)sample of premature newborns. All of the examined anomalies were found only in the category of marital distance "zero".
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 203-210
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 576.312
Original scientific paper
THE APPLICATION OF CYTOGENETIC ANALYSIS TO SAMPLES OF CHORIONIC VILLI
Marija DEBEVEC
University Clinic of Gynecology, University Clinical Center 61000 Ljubljana, Yugoslavia
Abstract
Debevec M. (1989): The application of cytogenetic analysis to samples of chorionic villl - Genetika, Vol. 21, No. 3, 203-210.
Various possibilities and problems related to the use of cytogenetic analysis of chorionic villus samples are presented. Basides the usual prenatal diagnostics in the early period of pregnancy (8th - 12th weeks), direct obtaining of chromosomes from the chorion or in later stages from the placenta, enables cytogenetic analysis in infected material of spontaneous abortions. This method can be used also for rapid prenatal diagnosis in later pregnancies (> 20 weeks) and in cases of suspect malformations on ultrasound scans.
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 211-219
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 618.39
Original scientific paper
CAUSES AND INCIDENCE OF HABITUAL ABORTIONS IN OUR POPULATION
Z. SINGER, K. PROFETA, M. PODOBNIK, M. BULIĆ, S. CIGLAR, V. KUKURA and N. SMILJANIĆ
Clinic for Gynaecology and Obstetrics, University hospital 'Dr Ozren Novosel', 41000 Zagreb, Yugoslavia
Abstract
Singer Z., K. Profeta, M. Podobnik, M. Bulić, S. Ciglar, V. Kukura and N. Smiljanić (1989): Causes and incidence of habitual abortions in our population. - Genetika, Vol. 21, No. 3, 211-219.
Couples with habitual miscarriages have been investigated in a prospective study covering the period 1981 - 1988. Diagnostic screening, observation and monitoring were carried out as well as application of preventive measures. In our research work we made use of clinical, genetic, microbiological, endocrinologic and immunogenetic methods.
In the investigations conducted so far, possible causes of infertility were discovered in 88% of all cases, while 12% remained unexplained. A prognosis of infertility is possible to make on the basis of detection of all external and unfavourable hereditary factors. Only then does it become possible to organize primary and secondary preventive measures.
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 221-235
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 575.1
Original scientific paper
HEREDITARY AND CONGINITAL MALFORMATIONS IN NEWBORN INFANTS IN VOJVODINA AND BOSANSKA KRAJINA REGIONS
M. VELISAVLJEV and R. TERZIĆ
Faculty of Medicine, Novi Sad, Banja Luka, Yugoslavia
Abstract
Velisavljev M. and R. Terzić (1989): Hereditary and congenital malformations in newborn infants in Vojvodina and Bosanska krajina regions. - Genetika, Vol. 21, No. 3, 221-235.
The absolute and relative (%) frequency of hereditary and congenital malformations has been investigated in newborn infants in Vojvodina (N = 58429; females 27979, males 30450) and Bosanska krajina (N = 40450; females 1972, males 20578) as well as the distribution of malformations according to the "status" (full-term, premature, stillborn) and the sex of the infant. A total of 85 different malformations has been registered (every 33-rd child) in the sample of newborn infants in Vojvodina in the period 1961-1986 and 109 in the sample of newborn infants in Bosanska krajina (every 28-th child) in the period 1985-1988.
Published in „GENETIKA“ Vol. 21, No.3 (1989), pp. 236-243
© 1989 Serbian Genetics Society
S. Bajića 1, 11185 Belgrade-Zemun
Serbia
UDC 612.64:616.076
Original scientific paper
FETAL TISSUE BIOPSY
B. RAJHVAN and A. KURJAK
Faculty of Medicine, 41000 Zagreb, Yugoslavia
Abstract
Rahvajn B. and A. Kurjak (1989): Fetal tissue biopsy. - Genetika, Vol. 21, No. 3, 236-243.
This review is about diagnostic techniques and therapeutic procedures in antenatal medicine. Our experience on performing 4.300 early amnicenteses, 133 chorion frondosum biopsies, 172 cordocenteses, 22 fetal skin biopsies and 86 therapeutic fetal tumour punctions is reported. There is a low rate complications if the procedure is performed by experienced staff using modern ultrasonic equipment. This justifiees widespread use of the described methods but only in high by specialized centres.