GENETIKA, Vol

GENETIKA, Vol. 6, No.3 (1974)

LJ. BERBEROVIĆ and R. HADŽISELIMOVIĆ

HISTORICAL VIEW OF CHANGES IN RELATIVE FREQUENCY OF TWO ALLELES IN HUMAN POPULATIONS [Abstract]

N. TUCIĆ

ANALYZIS OF LETHAL CHROMOSOMES AFTER SELECTION FOR RESISTANCE TO COLD TEMPERATURES IN DROSOPHILA MELANOGASTER. I. THE FREQUENCY OF IDENTICAL ALLELES AT DIFFERENT STAGES OF DEVELOPMENT [Abstract]

A. KAŠTELAN, Vesna KERHIN-BRKLJAČIĆ and Ljerka BRKLJAČIĆ

THE HL-A SYSTEM AND ITS BIOMEDICAL IMPLICATIONS [Abstract]

B. GARZIČIĆ, Danica KORAĆ, Ljiljana RUMENIĆ and Radmila RUŽIČIĆ

CYTOGENETICAL AND CLINICAL CHARACTERISTICS OF TWO CHILDREN WITH TYPICAL AND TRANSLOCATING TYPES OF »CRI DU CHAT« SYNDROME [Abstract]

Emilija STOJIMIROVIĆ, P. CVETKOVIĆ, Branislava AJDARIĆ, B. GARZIČIĆ, I. VUKOVIĆ and Danica KORAĆ

CHROMOSOME CHANGES DURING RADIATION AND HAEMOTHERAPY OF CHILDREN SUFFERING MALIGNANT DISEASES [Abstract]

F. BERGMANN

THE GENETICS OF SOME ISOENZYME SYSTEMS IN SPRUCE ENDOSPERM (PICEA ABIES) [Abstract]

DJ. NIKOLIĆ and F. BERGMANN

GENETIC VARIATION OF LEUCINE AMINOPEPTIDASE ISOENZYMES IN SEEDS OF PINUS NIGRA ARN. [Abstract]

L. EHRENBERG

GENETIC TOXICITY OF ENVIRONMENTAL CHEMICALS [Abstract]

Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 289-309

Serbia

Original scientific paper

HISTORICAL VIEW OF CHANGES IN RELATIVE FREQUENCY OF TWO ALLELES IN HUMAN POPULATIONS

LJ. BERBEROVIĆ and R. HADŽISELIMOVIĆ

Biološki institut Univerziteta u Sarajevu, 71 000 Sarajevo, Yugoslavia

Abstract

Berberović, Lj. and Hadžiselimović, R. (1974): Historical view of changes in relative frequency of two alleles in human populations. - Genetika, Vol. 6, No. 3, 289-309.

A total of 19033 data about individual ear lobe attachment phenotypes (free or attached lobe) has been collected by examining the appropriate historical records of unquestionable authencity (paintings, sculptures, photographs). Temporal and spatial (ethnical) aspects of the observed variation in the frequency of the two phenotypes have been studied.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 311-320

Serbia

Original scientific paper

ANALYZIS OF LETHAL CHROMOSOMES AFTER SELECTION FOR RESISTANCE TO COLD TEMPERATURES IN DROSOPHILA MELANOGASTER. I. THE FREQUENCY OF IDENTICAL ALLELES AT DIFFERENT STAGES OF DEVELOPMENT

N. TUCIĆ

Prirodno - matematički fakultet i Institut za biološka istraživanja, 11000 Beograd, Jugoslavija

Abstract

Tucić, N. (1974): Analysis of lethal chromosomes after se lection for resistance to cold temperatures in Drosophila melanogaster. I. The frequency of identical alleles at different stages of development. Genetika, Vol. 6, No. 3, 311-320.

A long-term selection of D. melanogaster has been performed during 48 generations, which significantly increased the resistance to cold - temperature treatments at each of five different developmental stages, namely eggs, larvae I, larvae II, pupae and adults. In each of the selected lines, the frequencies of homozygously lethal mutations were determined and an allelism test was performed. It has been stated that the relatively high proportion of identical lethals within each of the selected lines could be correlated with an increased resistance to cold temperatures of their carriers, in heterozygous combinations.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 321-338

Serbia

Original scientific paper

THE HL-A SYSTEM AND ITS BIOMEDICAL IMPLICATIONS

A. KAŠTELAN, Vesna KERHIN-BRKLJAČIĆ and Ljerka BRKLJAČIĆ

Centar za tipizaciju tkiva Klinike za urologiju Medicinskog fakulteta, Zagreb i Zavod za animalnu fiziologiju Prirodoslovno-matematičkog fakulteta Sveučilišta, 41 000 Zagreb, Jugoslavija

Abstract

Kaštelan, A., Kerhin-Brkljačić, V. and Brkljačić, Lj. (1974): The HL-A system and its blomedical implications. - Genetika, Vol. 6. No. 3, 321-338.

In this paper present knowledge of the genetics of the HL-A system, its importance in various fields of medicine such as tissue and organ transplantation, blood transfusion and pregnancy is described. Furthermore the relationship between the HL-A system and various diseases in men is presented.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 339-346

Serbia

Original scientific paper

CYTOGENETICAL AND CLINICAL CHARACTERISTICS OF TWO CHILDREN WITH TYPICAL AND TRANSLOCATING TYPES OF »CRI DU CHAT« SYNDROME

B. GARZIČIĆ, Danica KORAĆ, Ljiljana RUMENIĆ and Radmila RUŽIČIĆ

Laboratorija za humanu citogenetiku Instituta za biološka istraživanja, Beograd i Dečija klinika Medicinskog fakulteta, 11000 Beograd, Jugoslavija

Abstract

Garzičić, B., Korać, D., Rumenić, Lj. and Ružičić, R. (1974): Cytogenetical and clinical characteristics of two children with typical and translocating types of »cri du chat« syndrome. - Genetika, Vol. 6, No. 3, 339-346.

Two children with phenotypical characteristics of the syndrome »cri du chat« were analysed cytogenetically. The G-band technique in the proband No. 1 showed the breakage point in the short arm of chromosome 5 at the centromere level, i.e. pll. The karyotype of this girl was 46, XX, del (5) (pll) or more fully 46,XX,del(5)(pll:→qter). In proband No 2 (analysed before 1970) deletion of the short arm of a B chromosome with translocation was found. In this case, skin tissue culture and autoradiography were performed, besides the conventional method. The karyotype of the proband No 2 was 45,XY—21,5p—, + t(21q5p). The parents of both probands were healthy with normal karyotypes: the age of the mother were 29 and 26 years respectively.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 347-352

Serbia

Original scientific paper

CHROMOSOME CHANGES DURING RADIATION AND HAEMOTHERAPY OF CHILDREN SUFFERING MALIGNANT DISEASES

Emilija STOJIMIROVIĆ, P. CVETKOVIĆ, Branislava AJDARIĆ, B. GARZIČIĆ, I. VUKOVIĆ and Danica KORAĆ

Decija klinika Medicinskog fakulteta u Beogradu, 11000 Beograd, Jugoslavija

Abstract

Stojimirović, E., Cvetković, P., Ajdarić, B., Garzičić, B., Vuković, I. and Korać, D. (1973): Chromosome changes during radiation and haemotherapy of children suffering malignant diseases. - Genetika, Vol. 6, No. 3, 347-352.

In this paper the results of studies of chromosomes changes after therapeutic doses of radiation and cytostatics are presented. Two groups of patients were investigated. In the first group of 32 children chromosome analysis was performed before and after intense cytostatics therapy. The results of the analysis before therapy were within the normal limits (except in two cases-marker chromosome and Ph' chromosome). After therapy significant numerical and structural changes were found in ten children undoubtedly provoked by the therapy applied. In the second group (17) of patients the results of chromosome analysis before therapy were normal. After treatment changes were found in 7 patients, most frequently of the dicentric chromosome type.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 353-360

Serbia

Original scientific paper

THE GENETICS OF SOME ISOENZYME SYSTEMS IN SPRUCE ENDOSPERM (PICEA ABIES)

F. BERGMANN

Lehrstuhl für Forstgenetik und Forstpflanzenziichtung der Universitat Gottingen, 34 Gottingen-Weende, BRD

Abstract

Bergmann, F. (1974): The genetics of some isoenzyme systems in spruce endosperm (Picea abies). - Genetika, Vol. 6, No. 3, 353-360.

Using techniques of starch gel zone-electrophoresis, marked variability was detected in the SAP and LAP isoenzyme patterns found in the haploid endosperm of dry spruce seeds (Picea abies). Genetic analyses indicated that each of the polymorphic SAP and LAP zones studied is controlled by a distinct gene locus with several alleles. Linkage data showed that two AP and two LAP loci segregate independently while two EST loci appear to be located on the same chromosome.

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 361-365

Serbia

Original scientific paper

GENETIC VARIATION OF LEUCINE AMINOPEPTIDASE ISOENZYMES IN SEEDS OF PINUS NIGRA ARN.

DJ. NIKOLIĆ and F. BERGMANN

INEP, 11080 Zemun, Yugoslavia and Lehrstuhl f. Forstgenetik, Universität Göttingen, 3400 Göttingen, BRD

Abstract

Nikolić, Dj. and Bergmann, F. (1974): Genetic variation of leucine aminopeptidase izoenzymes in seeds of Pinus nigra Am. - Genetika, Vol. 6, No. 3, 361-365.

Female gametophytic endosperm tissue dissected from mature seed has been used for analysis of the genetic control of LAP (Leucine aminopeptidase) polymorphism, occurring in Pinus nigra from Yugoslavia. By starch gel zone-electrophoresis two distinct polymorphic zones of the LAP system were found in seed samples of Pinus nigra trees. It could be demonstrated that the LAP variation obtained is controlled by two separate gene loci with 5 alleles, two of which represent so-called zero--alleles (recessive type).

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Published in „GENETIKA“ Vol. 6, No.3 (1974), pp. 367-398

Serbia

Original scientific paper

GENETIC TOXICITY OF ENVIRONMENTAL CHEMICALS

L. EHRENBERG

Department of Radiobiology, Wallenberg Lab., University of Stockholm Lilla Frescati, S-104 05 Stockholm, Sweden

Abstract

Ehrenberg, L. (1974): Genetic toxicity of environmental chemicals.- Genetika, Vol. 6, No. 3, 367-398.

The ability of environmental chemicals to induce effects with a genetic mechanism is discussed. These effects which arc collectively called genotoxic, comprise gene mutation, cancer, some teratogenic effects and possibly some other diseases or harmful conditions.

The identification by epidemiological methods, of causative agents is rendered difficult because of the unspecificity of the effects, their late appearance and their appearance at very low exposure doses. Since the manifested effects are often drastic and irreverstible, causing suffering and economic losses, and since we possess no method to warn against a genetic catastrophy, chemicals spread intentionally or unintentionally in the environment have to be screened for potential genotoxicity.

Biological test systems have to be applied, although they appear in many cases to be too insensitive to exclude, in negative tests, an unacceptable risk. A determination of tissue doses, i.e. the time integrals of the concentrations in cells of the proximal genotoxic agents - mostly alkylating, arylating and other electrophilic reagents - is sufficiently sensitive for this purpose. This method which is applicable directly to man permits also quantitative risk estimates (in »rad-equivalents«) required for the risk-benefit evaluation of compounds of great importance to human nutrition, health and economy.

Viewpoints are given on required methods to decrease the genetic risk of pollutants.

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